Adult 500 mg as single dose daily for 3 days. Alternatively, initially 500 mg followed by 250 mg daily for a further 4 days. Uncomplicated genital infection caused by Chlamydia trachomatis & chancroid 1 g as single dose. Uncomplicated gonorrhea 2 g as single dose. Granuloma inguinale Initially 1 g followed by 500 mg daily, or 1 g once wkly for at least 3 wk, until all lesions have completely healed. Prophylaxis of disseminated MAC infection 1.2 g once wkly. Treatment or secondary prophylaxis 500 mg once daily in combination w/ other antimycobacterials. Mild to moderate typhoid caused by multidrug-resistant strain 500 mg once daily for 7 days.
Discontinue use if allergic reaction occurs. Does not treat viral infections. Pseudomembranous colitis. Prolonged cardiac repolarization & QT interval, imparting a risk of developing cardiac arrhythmia & torsades de pointes. Not to be simultaneously taken w/ Al & Mg-containing antacids. Hepatic impairment.
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